Revolutionary
Multi-Array SPR System
iMSPR-PlexM
iMSPR-PlexM은 비표지 방식 기반으로 다중 분자간 결합 분석을 위해 개발된 SPR 시스템입니다. 최소한의 샘플량을 사용하여 매우 짧은 시간안에 단일 칩에서 무려 250개의 분자간 결합을 모니터링 할 수 있는 혁신적인 시스템입니다.
icluebio에서 개발하고 SPR 센서 칩에 최적화된 자동 spotting robot인 iMSpot을 이용하여 사용자는 특정 실험 요구 사항에 맞게 리간드를 센서칩 위에 원하는 배열로 고정시킬 수 있습니다.
PlexM은 약물 발견의 초기 단계에서 후보물질을 스크리닝하는 분야에 최고의 선택이며 항체 약물의 epitope 연구 및 Fc receptor tests에 매우 효율적인 분석을 제공합니다.
Core Features
up to
250
interactions
for
10
minutes
less
1
microliter
With iMSpot, users can immobilize or capture ligand materials on the sensor chip in a precise spot pattern, tailored to their experimental needs. Using a 80 μm pin, up to 10 spots per unit area and a maximum of 250 spots can be arranged within a compact 5 x 5 mm ligand array zone. Once the sensor chip with ligand spots is mounted on the iMSPR PlexM, simply inject the analyte. This cutting-edge system enables the observation of up to 250 molecular interactions in just 10 minutes, offering unparalleled efficiency and throughput.
up to 250 spots/chip
10 spots / unit area
Multi-sensorgrams in 10 min
Maximize Efficiency with Minimal ligand Usage
Traditional SPR systems typically require around 200 μL to immobilize ligands in a single channel at concentrations ranging from 1–100 μg/mL. In contrast, iMSPR-PlexM revolutionizes this process with pin spotting technology, enabling the immobilization of multiple ligands on a single chip using less than 1 μL of sample at concentrations between 10–1000 μg/mL. With iMSPR-PlexM, you can significantly reduce ligand consumption while achieving precise and efficient results.
Sustainable hexagon type fluidics module
Through the hexagon(H)-type fluidics module, binding reactions can be performed with multiple ligands at once in a continuous flow manner. In addition, the H-type fluidics module can be used semi-permanently because it is manufactured as a PEEK-based unibody.
Streamline Drug Discovery with Advanced Kinetics Screening
The single-concentration kinetics screening function is highly effective during the early stages of drug discovery. Substances that meet or exceed the user-defined cut-off points for binding yield and kinetics values are highlighted in green, enabling users to easily identify hits from a large number of samples. For more precise evaluations, the system also supports experiments using multiple ligands at varying concentrations with a single analyte, delivering greater accuracy and deeper insights than single-concentration screening alone.
Specifications
PlexM
Includings
iMSPR-PlexM main system (1ea), Peristaltic pump with single channel (1ea), Degasser with single channel (1ea) H-type Fluidics module (1ea), Prism holder (1ea), Detach tool (1ea), PC (1ea),
Flat tweezer (1ea), Matching oil (3ml), USB cable (1ea)
Waranty
1 years
SPR system
SPR type
Reflect intensity measurement at fixed angle
Light source
Near IR LED
Detector
2D CMOS image sensor
Association range
10
3
10
6
to
M
-1
s
-1
Dissociation range
Affinity range
10
to
0.1
s
-1
10
-4
10
-11
to
M
-1
Noise level
1 RU
-5
Sample type
Small compounds, peptides, oligomers, lipids, proteins, cell-like molecules, Nano particles
DMSO resistance
10%